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Theophylline Information
Theophylline is a bronchodilator. It works by relaxing muscles in chest and the lungs, making the lungs sensitive to other causes of bronchospasm and allergens.Theophylline is used to treat symptoms like coughing or shortness of breathTheophylline may also be used for purposes.
Theophylline relaxes the smooth muscle of the bronchial airways and pulmonary arteries and reduces airway responsiveness to histamine, methacholine, adenosine, and allergen. Theophylline competitively inhibits type III and type IV phosphodiesterase (PDE), the enzyme responsible for breaking down cyclic AMP in smooth muscle cells, potentially leading to bronchodilation. Theophylline also binds to the adenosine A2B receptor and blocks adenosine mediated bronchoconstriction. In inflammatory conditions, theophylline activates histone deacetylase to stop transcription of inflammatory genes that need the acetylation of histones for transcription to begin.
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How to use theophylline
Follow the instructions. Do not take theophylline in smaller or larger quantities or for longer than advised. Your doctor may change your dose. Do not utilize theophylline to treat an asthma or bronchospasm attack. Use a fast acting antidepressant drugs. The amount and your dose will rely on the reason why you are taking this medication. Your dosage needs might change if you’re ill, or if a doctor changes type of theophylline, strength, or your brand. You’ll need regular evaluations to be sure you are using the dose.
Don’t change your medication dose or schedule without your physician’s advice. Take this medicine. Follow your physician’s directions about whether to carry your own medicine with food or on an empty stomach. Simply take exactly the exact same way every time to the medication. Do not crush, chew, break, or start an extended-release capsule or pill. Swallow it whole. Breaking or opening the pill could cause much of this medication.
If you don’t have a dose-measuring device, ask your pharmacist for one. This medication can affect the results of certain exams. Don’t start or stop smoking. Store at room temperature away from moisture, heat, and light.
Side Effects
- nausea
- vomiting
- insomnia
- headache
Interactions
Groups of patients breakdown theophylline gradually, and may create elevated blood levels and toxicity even on normal doses. These patients include patients taking medications that increase blood theophylline levels, elderly men with infants, patients with high fever, chronic lung ailments or heart failure, and those with liver disease. Examples of drugs that can raise blood levels include fluvoxamine ephedrine, allopurinol, cimetidine, ciprofloxacin, clarithromycin, itraconazole, ketoconazole, erythromycin, oral contraceptives, and propranolol.
Theophylline toxicity can cause agitation, vomiting, insomnia, seizures, nausea and life- threatening heart rhythm abnormalities. St. John’s Wort, rifampin, and carbamazepine reduce levels of theophylline and possibly its effect by raising its elimination. Levels and the effect of carbamazepine may decrease by increasing its elimination.
Theophylline is metabolized mainly by the liver and dosages should be lowered in patients with liver disorder. On the other hand, theophylline is generally metabolized more quickly in smokers and doses may be required.