Topiramate Calcium

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Brand Names
Qudexy XR, Topamax, Topiragen, Trokendi

Topiramate calcium Information

Topiramate is a seizure medication. Topiramate is used in the treatment of seizures in adults and kids that are at least 2 years old. Trokendi XR is for use in adults and kids who are at least 6 years old.Extended-release topiramate includes a higher minimum age When utilized as the child seizure medication. Even the Topamax and Qudexy brands of this medication can also be utilised to prevent migraine headaches in teenagers and adults who are 12 or more years old.

Topamax will only stop migraine headaches or reduce the amount of attacks. It won’t deal with.Topiramate may also be used for purposes.

Used for treatment: Alcohol Dependence, Binge Eating Disorder, Migraine Headaches, Refractory Status Epilepticus, Spasms, Infantile, Partial onset seizure Epilepsy, Primary generalized tonic-clonic seizure Epilepsy, Weight gain therapy

The precise mechanism of action of topiramate is not known. But, various studies have shown that topiramate blocks the action potentials elicited advertisements with a sustained depolarization of the neurons at a time-dependent manner, suggesting a state-dependent sodium channel blocking activity. Topiramate also augments the activity of the neurotransmitter gamma-aminobutyrate (GABA) at some subtypes of the GABAA receptor (controls an integral chloride channel), indicating a possible mechanism via potentiation of the activity of GABA. Topiramate also shows antagonism of this AMPA/kainate subtype of the glutamate excitatory amino acid receptor. It also inhibits carbonic anhydrase (particularly isozymes II and IV), but this activity is weak and unlikely to be associated with its anticonvulsant actions.

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How to use topiramate calcium

Follow all directions. Your dose may occasionally change. Don’t take this medication in larger or smaller amounts or for longer than recommended. Topiramate may be obtained with or without food. Do not crush, chew, or split a tabletcomputer. Swallow it whole. The Trokendi XR extended-release capsule must be swallowed whole.

Do not break or open. Topamax Sprinkle Capsule and even the Qudexy XR could be swallowed whole. Or maybe you open the capsule and sprinkle the medication into a spoonful of applesauce or other soft food. Swallow right away without chewing. Do not save the mixture for later usage. Carefully adhere to the swallowing instructions on your medication. You might need blood tests, when using topiramate. Should you require surgery, inform the physician ahead of time which you’re currently using topiramate.

Need to know that you take seizure drugs. Drink plenty of fluids while you are taking topiramate, to avoid an imbalance or kidney stones. Do not quit using topiramate abruptly, even in case you feel fine. Stopping abruptly may cause seizures. About tapering your own dosage, follow your physician’s instructions. Store at room temperature away from high heat, and light, moisture. Keep the bottle tightly closed when not in use.

Side Effects

  • Metabolic acidosis. Metabolic acidosis can cause:
    • tiredness
    • a change in the way foods taste
    • Effects on thinking and alertness. Topiramate may affect how you think and cause confusion, problems with concentration, attention, memory, or speech. Topiramate may cause depression or mood problems, tiredness, and sleepiness.
    • Dizziness or loss of muscle coordination.
    • diarrhea
    • nausea
    • upper respiratory tract infection
    • Kidney stones. Drink plenty of fluids when taking topiramate to decrease your chances of getting kidney stones.
    • High blood ammonia levels. High ammonia in the blood can affect your mental activities, slow your alertness, make you feel tired, or cause vomiting. This has happened when topiramate is taken with a medicine called valproic acid (Depakene and Depakote).
    • impaired consciousness
    • not feeling hungry
    • tingling of the arms and legs (paresthesia)
    • nervousness
    • irregular heartbeat
    • Low body temperature. Taking topiramate when you are also taking valproic acid can cause a drop in body temperature to less than 95В°F, feeling tired, confusion, or coma.
    • loss of appetite
    • weight loss


    The drugs, when taken with topiramate, raise the risk of metabolic acidosis dorzolamide dichlorphenamide and kidney stones. Phenytoin and Carbamazepine markedly reduce the amount of topiramate from the entire body by increasing its removal. As a result, topiramate may eliminate effectiveness unless doses are raised. The blood glucose levels may be increased by mixing acid with topiramate and lead to hypothermia.

    Topiramate may decrease the amount of estrogen in women taking oral contraceptives increasing the chances of breakthrough bleeding and pregnancy. Patients with seizure disorders taking drugs, such as topiramate, may develop nerve toxicity from a chemical, 4′-O-methylpyridoxine, seen as a contaminant in certain ginkgo preparations. Metabolic acidosis may be caused by Topiramate. Metformin is contraindicated in patients with metabolic acidosis.

    Topiramate may increase lithium levels at higher doses.