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Brand Names
Qudexy XR, Topamax, Topiragen, Trokendi

Topiramate Information

Topiramate is a seizure medication. Topiramate is used in the treatment of seizures in adults and children who are at least two years old. Trokendi XR is for use in adults and kids who are at least 6 years of age.Extended-release topiramate includes a high minimum age When used as the child seizure medicine. Even the Qudexy and Topamax manufacturers of this medication are utilized to prevent migraine headaches in adults and teens who are at least 12 years old. Topamax will only prevent migraine headaches or reduce the number of strikes.

It will not deal with.Topiramate may also be used for purposes not listed in this medication guide.

Used for treatment: Alcohol Dependence, Binge Eating Disorder, Migraine Headaches, Refractory Status Epilepticus, Spasms, Infantile, Partial onset seizure Epilepsy, Primary generalized tonic-clonic seizure Epilepsy, Weight gain therapy

The precise mechanism of action of topiramate is not known. However, various studies have shown that topiramate blocks the action potentials elicited repetitively with a sustained depolarization of the neurons at a time-dependent fashion, suggesting a state-dependent sodium channel blocking action. Topiramate also augments the action of the neurotransmitter gamma-aminobutyrate (GABA) at some subtypes of the GABAA receptor (controls an integral chloride channel), signaling a possible mechanism via potentiation of the action of GABA. Topiramate also demonstrates antagonism of the AMPA/kainate subtype of the glutamate excitatory amino acid receptor. It also inhibits carbonic anhydrase (especially isozymes II and IV), but this action is weak and unlikely to be related to its anticonvulsant actions.

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How to use topiramate

Follow all instructions. Your doctor may change your dose. Do not take this medicine in smaller or bigger amounts or for longer than suggested. Topiramate may be taken with or without meals. Do not crush, chew, or split a tablet that is topiramatecomputer. Swallow it whole. The Trokendi XR extended-release capsule has to be swallowed whole.

Do not open or break. Topamax Sprinkle Capsule and the Qudexy XR could be swallowed whole. Or you may open the capsule and sprinkle the medication. Swallow right away without chewing. Do not store the mixture for later usage. Follow the swallowing instructions on your medication. While utilizing topiramate, you might need regular blood tests. Should you need surgery, inform the surgeon ahead of time that you are using topiramate.

Any medical service provider that treats you ought to know that you just take seizure drugs. Drink lots of liquids while you’re taking topiramate, to avoid kidney stones or an electrolyte imbalance. Do not quit using topiramate even in the event you feel fine. Stopping abruptly may cause seizures that are increased. Follow your physician’s instructions. Call your physician if your seizures get worse or you have them more often while taking topiramate.

Shop away from moisture, light, and higher heat.

Side Effects

  • Metabolic acidosis. Metabolic acidosis can cause:
    • tiredness
    • a change in the way foods taste
    • Effects on thinking and alertness. Topiramate may affect how you think and cause confusion, problems with concentration, attention, memory, or speech. Topiramate may cause depression or mood problems, tiredness, and sleepiness.
    • Dizziness or loss of muscle coordination.
    • diarrhea
    • nausea
    • upper respiratory tract infection
    • Kidney stones. Drink plenty of fluids when taking topiramate to decrease your chances of getting kidney stones.
    • High blood ammonia levels. High ammonia in the blood can affect your mental activities, slow your alertness, make you feel tired, or cause vomiting. This has happened when topiramate is taken with a medicine called valproic acid (Depakene and Depakote).
    • impaired consciousness
    • not feeling hungry
    • tingling of the arms and legs (paresthesia)
    • nervousness
    • irregular heartbeat
    • Low body temperature. Taking topiramate when you are also taking valproic acid can cause a drop in body temperature to less than 95В°F, feeling tired, confusion, or coma.
    • loss of appetite
    • weight loss


    The following drugs, when taken with topiramate, increase the chance of kidney stones and metabolic acidosis: acetazolamide, dorzolamide, methazolamide, dichlorphenamide. Phenytoin and Carbamazepine markedly reduce the amount of topiramate from the entire body by increasing its removal. Unless doses are raised because of this, topiramate may eliminate effectiveness. The blood glucose levels may increase and lead to hypothermia.

    Topiramate may decrease the amount of estrogen in women taking oral contraceptives, potentially increasing the chances of pregnancy bleeding and unwanted pregnancy. Patients with seizure disorders taking anticonvulsant medications, such as topiramate, can develop nerve toxicity from a chemical, 4′-O-methylpyridoxine. Topiramate can cause metabolic acidosis. Metformin is contraindicated in patients with metabolic acidosis.

    Lithium levels can increase at doses that are higher.