Trazodone Hydrochloride

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Brand Names
Desyrel, Oleptro

Trazodone hydrochloride Information

Trazodone is an antidepressant medication. It affects chemicals.Trazodone has been used to deal with major depressive disease.Trazodone may also be used for purposes not listed in this medication guide.

Used for treatment: Alcohol Dependence, Anxiety, Insomnia, Major Depressive Disorder

Trazodone binds at 5-HT2 receptor, it functions as a serotonin agonist in high doses and a serotonin antagonist in low doses. Like fluoxetine, trazodone’s antidepressant activity likely results from congestion of serotonin reuptake by inhibiting serotonin reuptake pump at the presynaptic neuronal membrane. If used for extended time periods, postsynaptic neuronal receptor binding sites may also be impacted. The sedative effect of trazodone is likely the consequence of alpha-adrenergic blocking action and modest histamine blockade at H1 receptor. It weakly blocks presynaptic alpha2-adrenergic receptors and strongly inhibits postsynaptic alpha1 receptors. Trazodone doesn’t impact the reuptake of both norepinephrine or dopamine inside the CNS.

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How to use trazodone hydrochloride

Follow all instructions on your prescription label. Your doctor may sometimes change your dose. Do not take this medication in larger or smaller quantities or for longer than advised. The trazodone tablet needs to be taken following a snack or a meal. Take Oleptro in an empty stomach at bedtime or late in the day. Do not crush, chew, or split an extended-release tabletcomputer. If necessary an Oleptro tablet will break in half over the score line. It may take as many as two weeks before your symptoms improve.

Continue using the medicine and tell your health care provider if your symptoms do not improve. Do not stop using trazodone abruptly, or you might have withdrawal symptoms. Ask your doctor the way to safely quit using trazodone. Store at room temperature away from heat, moisture, and lighting.

Side Effects

  • attempts to commit suicide
  • feeling very agitated or restless
  • nausea/vomiting
  • new or worse irritability
  • thoughts about suicide or dying
  • dry mouth
  • panic attacks
  • new or worse anxiety
  • acting on dangerous impulses
  • other unusual changes in behavior or mood
  • drowsiness
  • acting aggressive, being angry, or violent
  • dizziness
  • new or worse depression
  • headache
  • trouble sleeping (insomnia)
  • an extreme increase in activity and talking (mania)


All antidepressants which raise concentrations of serotonin in the brain, including trazodone, shouldn’t be obtained with MAO-inhibitors. Medicines from the MAO-inhibitor class include phenelzine, isocarboxazid, tranylcypromine, and procarbazine . Such combinations may lead to confusion, high blood pressure and tremor. The kind of interaction could happen when trazodone is used with selegiline. When a patient is switched from trazodone at least one week ought to be allowed after quitting trazodone prior to the MAO inhibitor is begun.

After stopping an MAO inhibitor, fourteen days should elapse before beginning trazodone. Blood concentrations of phenytoin and digoxin have been reported in men taking due to a drop in the metabolism of these drugs by trazodone. Blood levels of trazodone may reduce by increasing its elimination. Ketoconazole, ritonavir, and indinavir inhibit the breakdown of trazodone resulting in increased blood levels of possible and trazodone side effects.

Bleeding may be caused by drugs that increase serotonin. Therefore, combining trazodone with other drugs that affect bleeding, nonsteroidal anti-inflammatory drugs, warfarin or aspirin might increase the probability of upper gastrointestinal bleeding.

Daisy on trazodone.