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Brand Names
Altinac, Atralin, Avita, Refissa, Renova, Retin-A, Solage, Tretin-X, Tri-Luma, Veltin, Vesanoid, Ziana

Tretinoin Information

Tretinoin is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body.Tretinoin is used to treat leukemia .Tretinoin may also be used for functions.

Used for treatment: Acne Vulgaris, FAB classification M3 Acute promyelocytic leukemia, Facial fine wrinkling, Mottled hyperpigmentation, Severe, recalcitrant Cystic acne, Tactile roughness of facial skin

Tretinoin equates to alpha, beta, and gamma retinoic acid receptors (RARs). RAR-alpha and RAR-beta have been associated with the progression of acute promyelocytic leukemia and squamous cell cancers, respectively. RAR-gamma is connected with retinoid effects on mucocutaneous tissues and bone. Even though the exact mechanism of action of tretinoin is unknown, current evidence suggests that the effectiveness of tretinoin in acne is caused mostly to its ability to transform abnormal follicular keratinization. Comedones form in follicles with an excess of keratinized epithelial cells. Tretinoin promotes detachment of cornified cells and the enhanced shedding of corneocytes from the follicle. By upping the mitotic activity of follicular epithelia, tretinoin also increases the metabolic rate of thin, loosely-adherent corneocytes. Through these actions, the comedo contents are extruded as well as also the creation of the microcomedo, the precursor lesion of acne vulgaris, is decreased. Tretinoin isn’t a cytolytic representative but instead induces cytodifferentiation and decreased proliferation of APL cells in culture and in vivo. When Tretinoin is given clinically to APL patients, tretinoin treatment produces an initial maturation of this primitive promyelocytes derived from the leukemic clone, followed by a repopulation of the bone marrow and peripheral blood from ordinary, polyclonal hematopoietic cells from patients achieving complete remission (CR). The exact mechanism of action of tretinoin in APL is unknown.

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How to use tretinoin

Adhere to all instructions. Don’t take this medication at smaller or larger quantities or for more than recommended.

Side Effects

  • numbness, burning, or tingling in the hands or feet
  • constipation
  • depression
  • confusion
  • fatigue
  • dry skin
  • weight loss
  • stomach pain
  • pain
  • diarrhea
  • difficulty falling asleep or staying asleep
  • rash
  • heartburn
  • feeling of fullness in the ears
  • headache
  • hallucinating (seeing things or hearing voices that do not exist)
  • extreme tiredness
  • loss of appetite
  • difficulty urinating
  • hair loss
  • agitation
  • dizziness
  • weakness
  • earache
  • flushing
  • bone pain
  • nervousness
  • fever
  • shivering


Mixing other topical acne medicines with tretinoin can lead to excessive skin irritation. Use of soaps or cleansers, astringents, skin waxes may add to skin irritation. Medications [tetracycline, for example] that cause sun sensitivity should not be combined with tretinoin due to sunlight sensitivity.