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Trimethoprim hydrochloride Information
Trimethoprim is an antibiotic that fights bacteria in your system.Trimethoprim is used to treat bladder or kidney ailments, or ear infections caused by bacteria.Trimethoprim might also be used for purposes not listed in this medication guide.
Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is a vital precursor from the thymidine synthesis pathway and disturbance for this pathway inhibits bacterial DNA synthesis. Trimethoprim’s affinity for bacterial dihydrofolate reductase is several thousand times greater than its affinity for human dihydrofolate reductase. Sulfamethoxazole inhibits dihydrofolate synthetase (aka dihydropteroate synthetase), a molecule involved further afield in the same pathway. Trimethoprim and sulfamethoxazole are commonly utilised in conjunction due to their synergistic results. This medication combination also decreases the development of resistance that is observed when either drug is used alone.
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How to use trimethoprim hydrochloride
Follow the directions. Do not take this medicine in larger or smaller quantities or for longer than advised. Take your medicine. Measure liquid medication with a distinctive dose-measuring cup or spoon, not a regular table spoon. If you do not own a dose-measuring device, ask your pharmacist. Take this medicine. Your symptoms may improve before the infection is completely cleared. Skipping doses may also raise. Trimethoprim won’t treat a viral infection such as flu or the frequent cold.
This medication can cause results with certain tests. Store at room temperature away from heat, moisture, and lighting.
Interactions
When a combination of sulfamethoxazole and trimethoprim was awarded with amantadine changes in 1 patient status occurred. Blood levels of phenytoin may be increased by treatment with trimethoprim. This may lead to reduced focus, and unwanted effects of phenytoin such as dizziness. Trimethoprim can also increase blood levels of digoxin and warfarin and lead to toxic effects.
Anemia, because of decrease in acid, can occur in individuals receiving trimethoprim in conjunction with: pyrimethamine, methotrexate, divalproex, valproic acid, triamterene, or trimetrexate. The combination of trimethoprim and cyclosporine may increase the chance of kidney damage from cyclosporine. When dapsone and trimethoprim are used collectively, increased blood levels of both drugs can occur with side effects that include a toxic condition of the blood known as methemoglobinemia.
The elimination of trimethoprim cans increase and may reduce the efficacy of trimethoprim.