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Trimethoprim sulfate Information
Trimethoprim is.Trimethoprim is used to treat kidney or bladder infections, or ear infections caused by bacteria.Trimethoprim may also be used for purposes.
Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is a vital precursor in the thymidine synthesis pathway and disturbance for this pathway inhibits bacterial DNA synthesis. Trimethoprim’s affinity for bacterial dihydrofolate reductase is several thousand times greater than its affinity for human dihydrofolate reductase. Sulfamethoxazole inhibits dihydrofolate synthetase (aka dihydropteroate synthetase), an enzyme involved farther afield in exactly the same pathway. Trimethoprim and sulfamethoxazole are commonly utilised in conjunction due to their synergistic effects. This drug combination also decreases the evolution of resistance that’s seen when either drug is used alone.
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How to use trimethoprim sulfate
Follow the directions. Do not take this medication in bigger or smaller amounts or for longer than advised. Take your medication. Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.
Take this medicine. Skipping doses may increase. Trimethoprim won’t take care of a viral infection such as the common cold or influenza. This medicine can cause odd results with certain medical evaluations. Tell any doctor who treats you that you’re using trimethoprim. Store at room temperature away from heat, moisture, and light.
Interactions
When a combination of trimethoprim and sulfamethoxazole was awarded with amantadine, changes in 1 patient status occurred. Blood levels of phenytoin may be increased by treatment with trimethoprim. This can lead to attention that is decreased, and unwanted effects of phenytoin like nausea. Blood levels of warfarin and digoxin also may increase and lead to serious effects. Anemia, due to a reduction in folic acid, can occur in individuals receiving trimethoprim in conjunction with: pyrimethamine, methotrexate, divalproex acid, triamterene, or trimetrexate.
The risk of kidney damage cans boost from cyclosporine. When dapsone and trimethoprim are utilized higher blood concentrations of both drugs can occur, sometimes with side effects that include a toxic state of the blood called methemoglobinemia. Rifampin may reduce the efficacy of trimethoprim and can raise trimethoprim’s removal by the kidneys.