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Trimethoprim Information
Trimethoprim is.Trimethoprim is used to treat kidney or bladder infections, or ear infections caused by bacteria.Trimethoprim might also be utilized for purposes.
Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor from the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis. Trimethoprim’s affinity for bacterial dihydrofolate reductase is several thousand times larger than its affinity for human dihydrofolate reductase. Sulfamethoxazole inhibits dihydrofolate synthetase (aka dihydropteroate synthetase), a molecule involved farther upstream in the same pathway. Trimethoprim and sulfamethoxazole are commonly utilised in conjunction due to their synergistic effects. This medication combination also decreases the evolution of resistance that is seen when either drug is used alone.
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How to use trimethoprim
Follow the directions. Don’t take this medicine in smaller or bigger amounts or for longer than suggested. Take your medicine. Measure liquid medication with a special dose-measuring cup or spoon, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. Take this medicine for the total period of time. Your symptoms may improve before the infection is completely cleared. Skipping doses can also increase your chance of further infection that is resistant to antibiotics.
Trimethoprim will not deal with a viral infection such as influenza or the common cold. This medication can cause results. Store at room temperature away from moisture, heat, and lighting.
Interactions
Changes in one individual’s psychological status occurred when a combination of sulfamethoxazole and trimethoprim was awarded with amantadine. Blood levels of phenytoin may be increased by treatment with trimethoprim. This may lead to attention, and side effects of phenytoin such as dizziness. Blood levels of digoxin and warfarin also may increase and result in toxic effects that are serious. Anemia, because of reduction in acid, can occur in persons receiving trimethoprim in conjunction with: triamterene, methotrexate, pyrimethamine, divalproex acid, or trimetrexate.
The combination of trimethoprim and cyclosporine may increase the risk of kidney damage from cyclosporine. When dapsone and trimethoprim are used together, increased blood concentrations of both drugs may occur with side effects which have a toxic state of the blood called methemoglobinemia. Rifampin may lower the effectiveness of trimethoprim and can raise trimethoprim’s elimination from the kidneys.