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Warfarin potassium Information
Warfarin is an anticoagulant . Warfarin reduces the formation of blood clots.Warfarin is used to treat or protect against blood clots in arteries or veins, which can lessen the chance of heart problems stroke, or other serious problems.Warfarin may also be used for purposes.
Warfarin inhibits vitamin K reductase, resulting in depletion of this low form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins, this restricts the gamma-carboxylation and following activation of the vitamin K-dependent coagulant proteins. The synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Depression of all of the four vitamin K-dependent coagulation factors (factors II, VII, and X) results in reduced prothrombin levels and a drop in the total amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of airways.
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How to use warfarin potassium
Follow all instructions. Your doctor may occasionally change your dose to make certain that to find the best results. Do not take warfarin in larger or smaller quantities or for longer than your doctor tells you to. Take warfarin. Never take a double dose. You could take warfarin with or without food. While taking warfarin, you’ll need regular “INR” or prothrombin time evaluations . Your blood work will help your physician decide the best dose for you. You must stay under the care of a physician when taking warfarin.
If you’ve received warfarin in a hospital, call or drop by your physician 3 to 7 days after you leave the clinic. Your INR will need to get tested at that time. Do not miss any follow-up appointments. Tell your health care provider if your body weight fluctuations, or even if you are ill with diarrhea, fever, chills, or flu symptoms. You may have to quit before having dental care or any surgery, taking warfarin 5 to 7 days.
Call your physician for instructions. You might have to quit taking warfarin in case you have spinal anesthesia or a spinal column, or should you have to take antibiotics . Ought to know that you are taking this medicine. Store away from moisture, heat, and mild.
Side Effects
- bloating
- diarrhea
- hair loss
- chills
- rash
- vomiting
- nausea
- stomach pain
- gas
- changes in taste
Interactions
Many medications can affect the activity of warfarin or raise the risk of bleeding. Patients on warfarin should regularly consult their doctor before instituting any medications. It also is advisable for patients on warfarin to carry identification such as bracelets to alert health professionals to the existence of anticoagulation. A couple of examples of drugs which interact with warfarin are: Medications that increase the effect of warfarin by reducing the breakdown of warfarin include amiodarone, trimethoprim/sulfamethoxazole, fluconazole, itraconazole, fluvastatin, fluvoxamine, metronidazole miconazole, voriconazole, zafirlukast, ciprofloxacin, cimetidine, atorvastatin, clarithromycin, fluoxetine, indinavir, and ritonavir.
Drugs that may lessen the effect of warfarin by increasing its breakdown include St. John’s wort, carbamazepine , rifampin, bosentan, and prednisone. Other anticoagulants such as dabigatran, argatroban, heparin, along with many others increase bleedingmedications like aspirin and other nonsteroidal anti-inflammatory medicationsserotonin reuptake inhibitors like paroxetine and fluoxetine. Garlic and ginkgo also increase the chance of bleeding because they cause bleeding when taken alone.
Foods with higher vitamin Ka> content reduce the effect of warfarin. Maintenance of a consistent intake of Vitamin K is important to prevent fluctuations in warfarin’s impact.