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Warfarin sodium Information
Warfarin is an anticoagulant . Warfarin reduces the formation of blood clots.Warfarin can be used to treat or prevent blood clots in veins or arteries, which can cut the chance of heart attack, stroke, or other severe problems.Warfarin may also be used for purposes.
Warfarin inhibits vitamin K reductase, resulting in depletion of this reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins, this restricts the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins. The synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Depression of three of the four vitamin K-dependent coagulation factors (factors II, VII, and X) contributes to reduced prothrombin levels and a drop in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots.
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How to use warfarin sodium
Follow all directions. Your physician may change your dose. Take warfarin. You could take warfarin with or without meals. While taking warfarin, then you will need regular “INR” or prothrombin time tests . Your blood work will help your physician decide the best dose for you. You must stay under the care of a physician while taking warfarin. When you have received warfarin in a hospital, then call or drop by your physician 3 to 7 days after you leave the hospital.
Your INR will need to be analyzed at that moment. Do not lose out on any followup appointments. Tell your physician if your own body weight changes, or if you are sick with fever, nausea, chills, or flu symptoms. You may want to quit prior to having any surgery or dental care taking warfarin 5 to 7 days. Call your physician for directions.
You might need to stop taking warfarin if you want to take antibiotics, or if you have a spinal tap or anesthesia . Wear a medical alert tag or carry an ID card stating that you take warfarin. Ought to know that you’re currently taking this medication. Store away from moisture, heat, and lighting.
Side Effects
- bloating
- diarrhea
- hair loss
- chills
- rash
- vomiting
- nausea
- stomach pain
- gas
- changes in taste
Interactions
Many medications raise the risk of bleeding or can impact the activity of warfarin. Prior to instituting any medicines on their 15, patients on warfarin should consult with their doctor. It also is advisable for patients on warfarin to carry identification such as bracelets to alert other health professionals. A couple of examples of drugs that interact with warfarin are: Drugs that increase the effect of warfarin by reducing the breakdown of warfarin include amiodarone, trimethoprim/sulfamethoxazole, fluconazole, itraconazole, fluvastatin, fluvoxamine, metronidazole miconazole, voriconazole, zafirlukast, ciprofloxacin, cimetidine, atorvastatin, clarithromycin, fluoxetine, indinavir, and ritonavir.
Drugs that may lessen the effect of warfarin by increasing its breakdown contain St. John’s wort, carbamazepine , rifampin, bosentan, and prednisone. Anticoagulants such as heparin, argatroban, dabigatran, and many others increase bleedingdrugs such as other nonsteroidal anti-inflammatory medications and aspirin, clopidogrel, and prasugrel; serotonin reuptake inhibitors like paroxetine and fluoxetine.
Garlic and ginkgo also raise the risk of bleeding because they cause bleeding when taken. Foods with higher vitamin Ka> articles decrease the effect of warfarin. Maintenance of a consistent intake of Vitamin K containing foods is important to prevent fluctuations in warfarin’s effect.