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Warfarin is an anticoagulant . Warfarin reduces the formation of blood clots.Warfarin can be used to cure or prevent blood clots in veins or arteries, which can reduce the chance of heart problems stroke, or other severe problems.Warfarin may also be utilized for purposes not listed in this medication guide.
Warfarin inhibits vitamin K reductase, leading to depletion of this low form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal areas of vitamin K-dependent proteins, this restricts the gamma-carboxylation and following activation of the vitamin K-dependent coagulant proteins. The synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Depression of three of the four vitamin K-dependent coagulation factors (factors II, VII, and X) results in reduced prothrombin levels and a drop in the total amount of thrombin generated and bound to fibrin. This lessens the thrombogenicity of clots.
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How to use warfarin
Follow all instructions. Your doctor may change your dose to be certain that to find the best results. Take warfarin at exactly the identical time every day. Never take a double dose. You might take warfarin with or without food. While taking warfarin, then you will need frequent “INR” or prothrombin time tests . Your blood work will help your physician determine the best dose for you.
When taking warfarin, you have to stay under the care of a doctor. Call if you have received warfarin at a hospital or see your physician 3 to 7 days after you leave the clinic. Your INR will need to be tested at that moment. Do not miss any follow-up appointments. Tell your physician if you are sick with fever, nausea, chills, or flu symptoms, or if your own body weight fluctuations.
You may need to quit before with any surgery or dental care taking warfarin 5 to seven days. Call your doctor. You might have to quit taking warfarin if you want to take antibiotics, or in case you have anesthesia or a spinal column . Should know that you’re currently taking this medication. Store at room temperature.
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Many drugs raise the chance of bleeding or can impact the anticoagulant activity of warfarin. Prior to instituting any medications on their 15, patients on warfarin should consult their physician. It is a good idea for patients on warfarin to carry identification for example bracelets to alert other health professionals into the presence of anticoagulation. A few examples of drugs which interact with warfarin are: Drugs that increase the effect of warfarin by reducing the breakdown of warfarin include amiodarone, trimethoprim/sulfamethoxazole, fluconazole, itraconazole, fluvastatin, fluvoxamine, metronidazole miconazole, voriconazole, zafirlukast, ciprofloxacin, cimetidine, atorvastatin, clarithromycin, fluoxetine, indinavir, and ritonavir.
Drugs that may reduce the impact of warfarin by increasing its breakdown include St. John’s wort, carbamazepine , rifampin, bosentan, and prednisone. Anticoagulants such as argatroban, heparin, dabigatran, and others increase bleedingdrugs such as other nonsteroidal anti-inflammatory drugs and aspirin, clopidogrel, and prasugrel; serotonin reuptake inhibitors such as fluoxetine and paroxetine. Garlic and ginkgo also increase the chance of bleeding since they cause bleeding when taken independently.
Foods with high vitamin Ka> content decrease the effect of warfarin. Maintenance of a constant intake of vitamin K is important to prevent fluctuations in the effect of warfarin.